Pharmacological properties Miconazole Cream
Miconazole Cream has a fungicidal effect on dermatophytes (Trichophyton rubrum, Trichophyton mentagrophytes, Eridermophyton floccosum, Microsporum canis), yeast and yeast-like fungi (Sandida albicans, etc.), as well as other pathogenic fungi (Malassezia furfur, Aspergillus niger, Penicillium crustaceum etc .). Miconazole nitrate inhibits the synthesis Biosyns-ergostirola and alters the lipid composition of the membrane, causing cell death of the fungus. Myco-nazol antibacterial effect more pronounced with respect to grampolozhi-negative bacteria (staphylococci, streptococci, etc.) and less pronounced against Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Proteus, etc.). The drug is moderately hyperosmolar activity, thus providing antiexudative action.
Pharmacokinetics Miconazole Cream
Systemic absorption of the drug for external use is very low. Rapidly destroyed in the liver.
Indications for Use Miconazole Cream
Fungal infections of skin and nail plate, caused by dermatophytes or yeast: Candida, Trichophyton, Epidermophyton, Malassezia furfur; mixed fungal or fungal-bacterial infections of the skin, secondary infection of skin grampolozhitel-governmental organisms.
Dosing and Administration Miconazole Cream
Cream gently rubbed into the affected skin 2 times a day, morning and evening. Applied to the complete disappearance of symptoms, and a few days to prevent relapse Islands. In the course of therapy is carried out mycological control, the results of which are determined by the duration of treatment.
In the treatment of onychomycosis after preliminary separation of the affected nail the plate is applied a thin layer of cream on the nail bed 1 – 2 times a day, followed by superposition-Niemi occlusive dressings. Treatment is carried out continuously until the final of formation of the new nail plate (not less than 3 months).
Features of Miconazole Cream
If the treatment of hypersensitivity reactions occur the drug should be noted the thread. Should not enter the drug in the eye. The cream when applied topically is not absorbed and can be used during pregnancy and lactation.
If it affects the nails should be cut to as short as possible.
If it affects the feet carefully handle the interdigital space.
Side effect Miconazole Cream
The drug is generally well tolerated. In rare cases there may be allergic skin reactions and a burning sensation.
Contraindications Miconazole Cream
Hypersensitivity to miconazole, and hepatic or renal insufficiency. For children under 3 years of cream prescribed under medical supervision.
Drug Interactions Miconazole Cream
Not recommended for use concomitantly with other ointments or creams.
